Endocrine Abstracts

Hypothalamic neuropeptide PACAP is a potent endogenous stimulator of adenylate cyclase synthesis in gonadotrope cells. Previously we found that, in contrast to GnRH, also Cu–GnRH complex is able to induce cAMP/PKA pathway activity.The aim of the study was to determine whether Cu–GnRH can act via GnRH-R and/or PAC-1 receptors to stimulate cAMP/PKA intracellular signaling. Moreover, we compared PACAP and Cu–GnRH ability to activate cGMP/PKG ...